England's Laura Davies, who won the title a record four times in a row in the mid-1990s, launches her American season at the Safeway International in Phoenix, Arizona.
The 44-year-old has not won on the LPGA tour for seven years but recently showed some real glimpses of her very best form and won a tournament in Austria on the Ladies' European Tour.
"I did play very well last year and definitely think I could win again in the States," said the player who needs two more victories or one major to gain her place in the LPGA Hall of Fame.
"I came close a few times and it was just a pity that I didn't manage to get another victory. But I'm confident going into the new season."
Kent's Karen Stupples is another former winner who had a fine end to last season, while Scot Catriona Matthew finished fourth last year.
This is the final event before the first of the women's majors - the Kraft Nabisco Championship at Mission Hills in California next week,.
Mexico's world number one Lorena Ochoa defends the title, while Sweden's Annika Sorenstam - a winner in Hawaii last month - continues her climb back to the top after a 2007 season that was ruined by injury.
The field includes two Canadians - Alena Sharp and Lorie Kane. Sharp is now the top Canadian on Tour after finishing 57th on last year's money list, 17 spots higher than four-time winner Kane whose last victory was way back in 2001.